Who we are
Philogen is a Swiss-Italian integrated biotechnology company founded in 1996, with the mission to develop innovative biopharmaceuticals for targeted therapy (
http://www.philogen.com). Philochem AG is the R&D department of Philogen and it is located in Zurich. Philogen-Siena focuses on product optimization/production according to GMP standards and on clinical trial investigations.
Job description
We seek an enthusiastic PhD student for an industrial doctorate program on drug discovery (Small Molecule Therapeutics research unit). Our focus is the discovery of small molecules against targets of pharmaceutical interest. The PhD candidate will apply DNA-encoded chemical libraries to identify new hits, followed by the design, synthesis and purification of small molecules using standard and advanced organic synthetic procedures. The candidate will also perform hit validation (i.e., Fluorescence polarization, Biacore, small molecule ELISA and/or enzymatic assays) to evaluate the biological activity of the synthesized compounds. Potentially, the PhD candidate will proceed with the most promising hits to test
in vitro (cellular assays) and
in vivo activity (murine models of cancer).
This program will be carried out in Zurich laboratories in collaboration with a European University. The student will be trained to:
- Design, plan and implement scientific projects related to the R&D drug discovery program associated with our DNA-Encoded Chemical Library (DECL) Technology.
- Scientific presentation and communication.
- Write scientific articles and publish on peer-reviewed scientific journals.
Minimum requirements
- Master Degree in chemistry, medicinal chemistry or related disciplines.
- Experience in synthesis (small organic ligands, peptide chemistry and bioconjugation chemistry is a plus) and characterization of organic compounds
- Experience with modern analytic techniques (HPLC, LC-MS) and interpretation of results obtained by spectroscopic techniques (LC-MS, NMR).
- Good knowledge of data analysis and editing Software (i.e Excel, Word, Power point, Prism, R, MatLab, Illustrator).
- Experience in performing literature searches using chemistry databases (PubMed, SciFinder, Reaxys) and in applying the results to solve synthetic challenges in the lab.
- Fluency in oral and written English.
Applications need to include a CV, letter of motivation and 2 reference letters.
If you are interested, please send your application to
samuele.cazzamalli@philochem.ch and
sebastian.oehler@philochem.ch.