BOARD


 

Alexandra Neri Carazzetti

She holds a BA in Business Administration from the Anglia Polytechnic University, Cambridge (UK).


 

Duccio Neri

Co-founder, CEO and President of Philogen. He graduated in Business Administration and Economics at the Bocconi University in Milan, specializing in Corporate Finance. Expertise in Financial Consulting, Tax and Audit Advisor and Business Administrator. Partner of the “Studio Neri – Tanini”. Formerly in the Board of the University of Siena as a representative of the Italian Government, formerly auditor of the Cassa di Risparmio di San Miniato (CRSM) S.p.A., MPS Banca Verde S.p.A., MPS Fiduciaria S.p.A., MPS Professional S.p.A., and of several firms.


Eveline Trachsel

Eveline Trachsel, born 15th September 1976, studied Pharmaceutical Sciences at the ETH Zurich, Switzerland. After a 4-months internship in the GMP production of antibodies at Philogen S.p.A. in Siena, Italy, she worked with Prof. Dr. Dario Neri on ligand-based targeting of inflammatory diseases. She earned her PhD in 2006 for which she has been awarded the GSIA prize 2007 and the 2nd prize in the DSM Award (South) 2007.Eveline Trachsel is a co-author of more than 15 scientific publications in peer-reviewed journals and she serves as a member of the ethical commitee of the Canton of Aargau. Currently, Eveline Trachsel is „Head of Therapeutic Antibody Research“and Member of the Board. She is mainly involved in the preclinical development of ligand-based therapeutics as well as the clinical development of Philogen’s antibody-based products.


 

KEY SCIENTISTS


Alessandra Villa

Alessandra Villa, born 20th September 1981, studied Industrial Biotechnology at Universita’ degli Studi of Milan-Bicocca where she got the Master Degree in 2005 with a thesis entitled: “Directed Evolution of an Enzyme Stability”. From 2006 to 2008 she performed her PhD at ETH Zurich on generation of phage display libraries and isolation of vascular targeting antibodies, under the guidance of Prof. Dario Neri. Since 2009, Alessandra is “Head of Antibody Library Technology” and her work is mainly focused on the isolation of monoclonal antibodies against antigens of biological relevance, single-pot and affinity-maturation antibody libraries design and construction.


Giulio Casi

Giulio Casi, born 2nd May 1975, studied chemistry with focus in organic synthesis, at Florence University in Italy. After one year training under the supervision of Dr. Agnes Bombrun in the medicinal chemistry department of Serono pharmaceutical research institute in Geneva, Switzerland, he joined the laboratory of Prof. Donald Hilvert in ETH Zurich, Switzerland, where he worked at the interface between chemistry and biology for the assembly of a semi synthetic enzyme. For this work Giulio Casi was awarded a PhD degree at the end of 2007. After completing enzymatic characterization and collaborative work with Prof. Dieter Seebach, in 2009 he joined the department of rare reagents at Roche Diagnostics in Penzberg, Germany, where he worked as a postdoctoral fellow on the development of synthetic antigens. Giulio Casi is co-author of several publications in peer-reviewed journals. Since November 2009 Giulio Casi joined Philochem AG where, as “Head of Antibody-drug conjugates” (ADCs), he is responsible for the engineering of innovative linkers for the controlled release of drugs in ADCs, and for the development novel cytotoxic drugs.


Kathrin Schwager

Kathrin Schwager, born 22nd September 1981, studied Pharmaceutical Sciences at ETH Zurich, Switzerland, and performed her diploma thesis “ Protein Engineering of Novel Antibody-Cytokine Fusions” in 2005 with Prof. Dr. Dario Neri. From 2007 until 2010 she worked on her PhD thesis “Recombinant antibodies for the imaging and treatment of rheumatoid arthritis and endometriosis” under the supervision of Prof. Dr. Dario Neri at Philochem AG as a PhD student at ETH Zurich, Switzerland. Since 2010 she is responsible of the “Preclinical research” at Philochem AG.


Luca Mannocci

Luca Mannocci, born 7th September 1979, studied Chemistry at the University of Pisa, Italy, and in 2004 performed his diploma thesis “First Total Synthesis of Naturally Occurring (-)-Nitidon and Its Enantiomer”under the supervision of Prof. Adriano Carpita and Prof. Renzo Rossi. From 2005, he worked in the group of Prof. Dr. Dario Neri, at ETH Zurich where he earned his PhD in 2008 with the thesis “DNA Encoded Chemical Libraries”. Luca Mannocci is an author and co-author of several scientific publicationsin peer-reviewed scientific journals. Currently, Luca Mannocci is “Head of DNA-encoded chemical libraries and lead discovery” and his main area of activity relates to the development and use of DNA-encoded chemical libraries technology for pharmaceutical applications.


Manuela Kaspar

Manuela Kaspar, born 17th August 1978, studied Pharmaceutical Sciences at the ETH Zurich (Switzerland) and performed her diploma thesis with Prof. Dr. Dario Neri in the field of anticancer immunoconjugates in 2003. From 2004 she worked in the Lab of Prof. Dario Neri on ligand-based targeting and therapy of cancer and earned her PhD in 2007. She did a 2-months training in the GMP production of antibodies at Philogen SpA in Siena (Italy). Manuela Kaspar is a co-author of more than 15 scientific publications in peer-reviewed journals. Currently, Manuela Kaspar is “Head of Protein Engineering” at Philochem AG. Her main task is the pre-clinical development of ligand-based therapeutics and imaging agents as well as the clinical development of Philogen’s antibody-based products.


Sarah Wulhfard

Sarah Wulhfard, born 21st January 1980, studied Industrial Biotechnology at the Universita’ degli Studi di Torino, Italy, and performed her diploma thesis “Development of analytical techniques in capillary electrophoresis with laser induced fluorescence for the analysis of proteins: focusing on transgenic proteins applications” in 2003. In 2004 she worked as an intern at the Drug Delivery System Department of Serono SA, Italy, where she developed new analytical methods for the analysis of protein aggregation state by capillary electrophoresis. From 2005 until 2009 she worked in the group of Prof. Florian Wurm at the Laboratory of Cellular Biotechnology of the EPFL, Switzerland, where she earned her thesis “Transient recombinant protein expression in mammalian cells: the role of mRNA level and stability” in 2009. In July 2009 she joined Philochem as “Head of cell line development”. She is in charge of engineering mammalian cell lines for the expression of new therapeutic antibodies for vascular tumor targeting.


Tim Fugmann

Tim Fugmann, born 6th October 1979, studied technical Biology at the University of Stuttgart, Germany and after a one year internship at Monsanto in Tokyo (Japan), in 2006 he performed his diploma thesis “Characterization of a novel PKD phosphorylation site on the CERT protein” in the laboratory of Prof. Dr. Klaus Pfizenmaier at the Institute of Cell Biology and Immunology of Stuttgart, Germany. From 2007 he worked in the Lab of Prof. Dario Neri and in 2010 earned his PhD with the thesis “Innovative methodologies for the proteomic discovery of vascular markers in cancer and kidney disease”. Tim Fugmann has published several articles in peer-reviewed scientific journals and since 2010, he is responsible for the “Discovery of Vascular Targets” at Philochem.


Valeria Lovato

Valeria Lovato, born 24th July 1980, studied Pharmaceutical Biotechnology at the Universitá degli Studi di Padova, Italy, and performed her diploma thesis “Molecular analysis of the excalibur gene in Drosophila Melanogaster” under the guidance of Prof. Dr. Barbara Gatto and Prof. Dr. Michael Hoch at the Universität Bonn, Germany. From 2005 until 2009 she worked in the group of Prof. Dr. Dario Neri where she earned her PhD thesis “Antibody phage display technology: library construction and application”. Since 2009 she is “Clinical Research Manager” at Philochem.


 

SCIENTIFIC ADVISORY BOARD


Christoph Rösli

Christoph Rösli, born 20th August 1979, studied Biology at the ETH Zurich, Switzerland and performed his diploma thesis “Proteomic analysis of membrane proteins” in the laboratory of Prof. Dr. Dario Neri in 2003. From 2004 he worked in the Lab of Prof. Dario Neri on novel methodologies for the identification and relative quantification of proteins in biological samples and earned his PhD in 2007. Christoph Rösli has published more than 20 articles in peer-reviewed scientific journals.Since 2007, he is Consultant of Philochem AG (Zürich, Switzerland) in the field of vascular marker discovery.


Dario Neri

Dario Neri is a Founder of Philogen and of Philochem, and Full Professor of Biomacromolecules at the Department of Chemistry and Applied Biosciences of the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland.

Born in Rome (Italy) on 1st May 1963, Dario Neri studied at the Liceo Classico E.S. Piccolomini in Siena and Chemistry at the Scuola Normale Superiore of Pisa, graduating in 1987 with a thesis on the synthesis and characterization of complex polyunsaturated secondary metabolites, isolated from higher plants. In 1992, he earned his doctorate in chemistry under Prof. Dr. Kurt Wüthrich at the Institute of Molecular Biology and Biophysics of the ETH Zurich. His dissertation was awarded the ETH Zurich silver medal. With an EU Bridge Bursary, he spent four years at the Cambridge Centre for Protein Engineering, Medical Research Council, where he worked under the supervision of Sir Gregory Winter. He has now been a Professor at the ETH Zurich since 1996. Dario Neri has published over 190 articles in peer-reviewed scientific journals and is inventor in numerous patents. He is the recipient of the ISOBM Abbott Prize 2000, of the Amgen-Dompe’ Biotec Award 2000, of the Mangia d’Oro 2001, of the Prous Award 2006 of the European Federation of Medicinal Chemistry, of the Robert-Wenner-Prize 2007 of the Swiss Cancer League and of the SWISS BRIDGE Award 2008.


Jörg Scheuermann

Jörg Scheuermann, born 16th April 1970 in Mannheim, Germany, received a BS degree in chemistry from the Ruprecht-Karls-University Heidelberg/Germany and a MS degree in chemistry from the ETH Zurich where he performed his master thesis in the field of non-standard DNA bases under the supervision of Prof. Steven A. Benner. For his PhD studies he joined the laboratory of Prof. Dario Neri where he worked on the isolation of novel low-molecular weight binding molecules and high-affinity antibodies to the EDB domain of fibronectin, a marker of angiogenesis. He continued to work with Prof. Neri first as a postdoctoral fellow, now as permanent scientific employee and habilitand in the development of DNA-encoded chemical library technology, most specifically on the development of ESAC (Encoded Self-Assembling Chemical) library technology and its application in drug discovery and development. Since 2007, he is Consultant of Philochem AG (Zürich, Switzerland) in the field of DNA encoded chemistry.